Associations Between Polygenic Risk for Alzheimer's Disease and Grey Matter Volume Are Dependent on APOE, Pathological and Diagnostic Status.

ABSTRACT:

Background/objectives

Studies have shown that higher polygenic risk scores (PRSs) for Alzheimer's disease (AD) are associated with smaller volumes in temporal brain regions typically affected by this disease. These effects have also been found in cognitively unimpaired (CU) older adults. This study aimed to investigate the relationship between PRSs and brain volumes in specific areas associated with early AD.

Methods

342 participants were selected from the Alzheimer's Disease Neuroimaging Initiative and stratified into three groups: 114 amyloid-positive atrophic (A+N+), 114 amyloid-negative non-atrophic (A-N-), and 114 amyloid-positive non-atrophic (A+N-) people. Linear regressions were performed within each group to investigate associations between PRSs and regional grey ma

SUBMITTER: Nocella V 

PROVIDER: S-EPMC12562698 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature