Dissecting epigenetic age acceleration in amyotrophic lateral sclerosis.

ABSTRACT:

Aim

We compared signatures of epigenetic aging in amyotrophic lateral sclerosis (ALS) patients and healthy controls to investigate the role of potential confounders and genetic subgroups.

Methods

We used whole-blood methylome profiles for 5,146 ALS patients and 2,156 controls available for Project MinE. We predicted biological age with three generations of epigenetic clocks and estimated age acceleration by regressing our model on control individuals to evaluate case/control differences. To investigate the contribution of C9orf72 expansions, we regressed the model on C9orf72-negative ALS patients. The predicted DunedinPACE pace of aging and telomere length additionally characterized aging dynamics.

Results

We found that white blood cell type proportions

SUBMITTER: Merbaum P 

PROVIDER: S-EPMC12562728 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature