Antihyperuricemic Effects of <i>Cornus officinalis</i> Extract via URAT1 Regulation and Renoprotective Mechanisms.

ABSTRACT: Hyperuricemia, characterized by elevated serum uric acid levels, is a major risk factor for gout and kidney disease. This study evaluated the antihyperuricemic effects of Cornus officinalis extract (COE) using urate transporter 1 (URAT1)-expressing oocytes and a hyperuricemia rat model. COE effectively inhibited uric acid absorption by modulating URAT1, with an IC₅₀ value of 3.24 µg/mL. In the hyperuricemia model, COE administration (100 and 200 mg/kg) significantly reduced serum uric acid levels and increased urinary uric acid excretion. The primary constituents of COE, morroniside (MO) and loganin (LO) exerted similar effects, with MO exhibiting potent inhibition of uric acid absorption even at low concentrations. Kidney tissue analysis revealed a reduction in blood ure

SUBMITTER: Sung YY 

PROVIDER: S-EPMC12562802 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature