Whole-genome analysis of rotavirus G1P[8] and other Wa-like strains in Mozambican children: evidence of genetic variations of pre-vaccine G1P[8] strains from Manhica, Mozambique.

ABSTRACT: The Rotarix® (GlaxoSmithKline, Rixenstart, Belgium) vaccine was adopted into the Expanded Program on Immunization in Mozambique in September 2015, and G1P[8] strains were frequent pre- and post-vaccine introduction in some regions of the country. In the current study, G1P[8] and other strains (G12P[6], G12P[8] and G9P[8]) circulating between 2008-2012 and 2015 in children with and without diarrhoea were characterized by next-generation sequencing to understand their genetic composition. The G1P[8] strains were compared with Mozambican pre- and post-vaccine strains retrieved from GenBank. All study strains, either from children with or without diarrhoea, were genetically similar and exhibited a typical Wa-like constellation. The Mozambican pre- and post-vaccine G1 strains clustered in two s

SUBMITTER: Manjate F 

PROVIDER: S-EPMC12562872 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature