Influence of Lifestyle on Brain Sensitivity to Circulating Insulin-like Growth Factor 1.

ABSTRACT: Lifestyle factors, including social relationships and diet, influence mood homeostasis, a mechanism often dysregulated in high-incidence mental illnesses like depression and Alzheimer's dementia (AD). Given that insulin-like growth factor 1 (IGF-1) modulates mood and its blood levels are altered in both AD and affective disorders, we investigated whether IGF-1 activity in the brain was affected in mice subjected to social isolation or a high-fat diet (HFD). We found that both lifestyle conditions increased anxiety and depression-like behavior in C57BL/6 mice of both sexes, as determined by the elevated zero maze/open field tests and the forced swim test, respectively. These lifestyle conditions were associated with loss of neuronal responses to systemic IGF-1. Enhanced neuronal activity in

SUBMITTER: Zegarra-Valdivia J 

PROVIDER: S-EPMC12562898 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature