Determinants of Chain Selection and Staggering in Heterotrimeric Collagens: A Comprehensive Review of the Structural Data.

ABSTRACT: Collagen is a family of large, fibrous biomacromolecules common in animals, distinguished by unique molecular, structural, and functional properties. Despite the relatively low complexity of their sequences and the repetitive conformation of the triple helix, which is the defining feature of this family, unraveling sequence-stability and structure-function relationships in this group of proteins remains a challenging task. Considering the importance of the structural aspects in collagen chain recognition and selection, we reviewed our current knowledge of the heterotrimeric structures of non-collagenous (NC) regions that lack the triple helix sequence motif, Gly-X-Y, and are crucial for the correct folding of the functional states of these proteins. This study was conducted by simultaneous

SUBMITTER: Vitagliano L 

PROVIDER: S-EPMC12562938 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature