Structure-Function Insights into Frog Skin Peptides Reveal Potent Inhibition of West Nile Virus Entry.

ABSTRACT: Over the past five decades, the emergence and re-emergence of multiple flaviviruses have triggered significant global outbreaks, posing serious threats to public health. Among them, West Nile virus (WNV) is a major cause of mosquito-borne illness, typically presenting as an acute systemic febrile disease and, in some cases, progressing to the central nervous system involvement. No specific antiviral therapies or effective vaccines are available for WNV infections. In this context, antimicrobial peptides (AMPs) with antiviral properties-known as antiviral peptides (AVPs)-have gained attention as potential therapeutic agents due to their ability to interfere with various stages of the viral life cycle. Two frog-derived melittin-like peptides, AR-23 and RV-23, were synthesized and purified, a

SUBMITTER: Zannella C 

PROVIDER: S-EPMC12563094 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature