Optimization of EPA-Nattokinase Nanoemulsions Processed by High-Pressure Homogenization to Enhance Stability and Thrombolytic Efficacy.

ABSTRACT: This study leverages nanoemulsion technology to engineer a novel liquid formulation combining Eicosapentaenoic acid (EPA) and Nattokinase (NK), aiming to enhance their application potential in functional foods. Both EPA and NK are well recognized for their pronounced anti-thrombotic, anti-inflammatory, and lipid-lowering properties, which are critical for the prevention and management of cardiovascular diseases. However, their practical application in functional foods is hampered by inadequate gastrointestinal stability and suboptimal bioavailability. Here, an EPA-NK nanoemulsion was fabricated using high-pressure homogenization technology. We systematically evaluated its environmental stability, anti-thrombotic activity, and intervention efficacy against carrageenan-induced black-tail thr

SUBMITTER: Wang J 

PROVIDER: S-EPMC12563103 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature