Lesion Stiffness Measured by Magnetic Resonance Elastography: A Novel Biomarker for Differentiating Benign, Premalignant and Malignant Prostate Lesions.

ABSTRACT: Background/Objectives: This study aimed to assess whether magnetic resonance elastography (MRE)-derived stiffness measurements of the central gland, entire gland, and lesions of the prostate differ among benign, premalignant, and malignant lesions and to evaluate their diagnostic performance in distinguishing these groups. Methods: This prospective study enrolled 113 men (mean age, 62.7 ± 7.2 years). Patients were categorized into benign (n = 75), premalignant (n = 15; atypical small acinar proliferation and high-grade prostatic intraepithelial neoplasia), and malignant (n = 23; adenocarcinoma) lesion groups based on histopathological findings. MRE-derived stiffness was measured at the lesion, central gland, and entire gland levels. Other evaluated parame

SUBMITTER: Pocan S 

PROVIDER: S-EPMC12563254 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature