Fabrication and Characterization of Electrospun Keratin Mats with <i>Echinacea purpurea</i> L. and Biosynthesized Silver Nanoparticles.

ABSTRACT: This study presents the development of antibacterial electrospun nanofibrous mats composed of keratin and polyethylene oxide, incorporating Echinacea purpurea L. (EchP) and green-synthesized silver nanoparticles (bioAgNPs) produced using EchP extract. The successful synthesis of bioAgNPs was confirmed by colorimetric analysis, FTIR, XRD, and TEM. In vitro assays demonstrated antibacterial activity against both Gram-positive and Gram-negative bacteria at ~0.6 µg/mL. Keratin, extracted from sheep wool, retained partial native structure, supporting biocompatibility and cellular regeneration. Incorporation of EchP or bioAgNPs reduced solution viscosity by 25-45%, significantly affecting mat morphology and shifting fiber diameters toward the 50-1

SUBMITTER: Andziukeviciute-Jankuniene A 

PROVIDER: S-EPMC12563298 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature