RNA Interference and Its Key Targets for Spinal Cord Injury Therapy: What Is Known So Far?

ABSTRACT: Spinal cord injury (SCI) is a neurological condition often resulting in permanent motor and sensory deficits, for which effective treatments remain limited. RNA interference (RNAi) is a post-transcriptional mechanism of the downregulation of gene expression mediated by small interfering RNAs. RNAi has demonstrated therapeutic efficacy in various neurological disorders, positioning it as a promising yet underexplored therapeutic strategy for SCI. Here, we provide a focused overview of the key pathological processes in SCI, including primary mechanical injury and secondary cascades such as inflammation, mitochondrial dysfunction, excitotoxicity, oxidative stress, multiple forms of cell death, and others. The potential of RNAi to selectively silence genes implicated in these pathological proc

SUBMITTER: Chudakova D 

PROVIDER: S-EPMC12563420 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature