Increased EGFR/HER2 Pathway Activation Contributes to Skin Tumorigenesis in <i>Tpl2</i>^-^/- Mice.

ABSTRACT: Background: The mitogen-activated protein kinase (MAPK) signaling pathway is frequently dysregulated in cutaneous squamous cell carcinoma (cSCC). Tumor progression locus 2 (Tpl2), a serine/threonine protein kinase within the MAPK family, regulates cellular proliferation, survival, and inflammatory responses. Loss of Tpl2 activates compensatory signaling cascades, driving increased papilloma and cSCC development. In this study we examined whether dysregulated ErbB signaling contributes to the enhanced tumor burden found in Tpl2^-/- mice. Methods: To evaluate whether aberrant ErbB signaling drives tumorigenesis in Tpl2^-/- mice, wild-type (Tpl2^+/+) and Tpl2^-/- mice were subjected to a two-stage chemica

SUBMITTER: Purkey LR 

PROVIDER: S-EPMC12563468 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature