Analysis of the Phenolic Profile of <i>Chelidonium majus</i> L. and Its Combination with Sericin: Balancing Antimicrobial Activity and Cytocompatibility.

ABSTRACT: The incorporation of bioactive natural compounds into biomedical applications offers a promising route to enhance therapeutic efficacy while supporting sustainability. In this study, we investigated the synergistic potential of Sericin, a silk-derived biopolymer, and Chelidonium majus L. (C. majus), a medicinal plant with a diverse phenolic profile, in relation to biological activities relevant for wound care and infection control. A combined experimental strategy was applied, integrating detailed chemical characterization of C. majus extracts with antimicrobial and cytocompatibility assays across different Sericin-plant extract ratios (1:1, 1:2, 2:2, and 2:1). Phytochemical analysis identified and quantified 57 phenolic compounds, including high levels of flavonoids (

SUBMITTER: Borges A 

PROVIDER: S-EPMC12563533 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature