Unraveling Lyophilization and Redispersion Effects on Miktoarm Polymer-Based Nanoformulations.

ABSTRACT: To enhance the scope of therapeutic interventions using star polymeric nanoparticles of desired concentrations, an understanding of the effect of converting aqueous formulations into stable redispersible dry powders by freeze drying on their physicochemical and biological properties is essential. We demonstrate that parameters such as the choice of the cryoprotectant, its molecular weight, and concentration play an important role during lyophilization and reconstitution processes. We hypothesized that utilizing cryoprotectants akin to shell-forming polymers may be ideal in protection against aggregation and keeping the nanostructures intact during lyophilization and reconstitution, as well as retaining the overall biological efficacy of their cargo. Through an evaluation of miktoarm polyme

SUBMITTER: Yousefi Adlsadabad S 

PROVIDER: S-EPMC12563623 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature