Fungal Biotransformation of Chloroflavanones and Antimicrobial Activity of Parent Compounds and Derived Products.

ABSTRACT: This study explores the synthesis of chlorine-substituted flavanones and their biotechnologically derived glycosides in order to evaluate how structural modifications influence both antimicrobial activity and pharmacokinetic properties, with attention to issues such as solubility and membrane transport. Four chloroflavanones (2'-, 3'-, 4'-, and 6-chloroflavanone) were synthesized and biotransformed using entomopathogenic fungi to obtain glycosylated derivatives. Antimicrobial activity was assessed against five microbial strains, while pharmacokinetic properties were predicted computationally. Results showed that 4'-chloroflavanone demonstrated the strongest antimicrobial activity, particularly against Gram-positive bacteria Staphylococcus aureus ATCC 29213 and Enterococcus faecal

SUBMITTER: Krawczyk-Lebek A 

PROVIDER: S-EPMC12563750 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature