Permeabilize, but Choose Wisely: Selective Antibiotic Potentiation Through Outer Membrane Disruption in <i>Pseudomonas aeruginosa</i>.

ABSTRACT: Most clinically used antibiotics exert their effects by targeting essential intracellular components of bacterial cells. Therefore, enhancing their ability to traverse the bacterial envelope is crucial for restoring or improving therapeutic efficacy. We investigated the potential of outer membrane (OM)-disrupting agents-EDTA, NV716, colistin, and squalamine-to potentiate antibiotic activity against the multi-drug-resistant pathogen Pseudomonas aeruginosa. Our objective was to assess the therapeutic value of this strategy while also delineating its limitations by comparing responses across antibiotic classes with diverse chemical structures and pharmacological profiles. Beyond lipophilicity, we analyzed three additional physicochemical descriptors likely to influence OM permeability:

SUBMITTER: Novelli M 

PROVIDER: S-EPMC12563807 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature