Multiomics Investigation of Exhausted T Cells in Glioblastoma Tumor Microenvironment: <i>CCL5</i> as a Prognostic and Therapeutic Target.

ABSTRACT: Glioblastoma multiforme (GBM) is a common malignancy with poor prognosis, and exhausted T (TEX) cells, a subset of T cells characterized by progressive loss of effector functions, play a critical role in its progression. This study aimed to investigate the impact of TEX-related genes on immune function, prognosis, and drug sensitivity in GBM through multiomics analysis. Initially, we identified a novel set of TEX-related genes specific to GBM and screened hub genes (CCL5, IL18, CXCR6, FCER1G, TNFSF13B) using conventional statistical methods combined with machine learning. A prognostic risk model was subsequently constructed based on TCGA data and validated in the CGGA cohort. Single-cell and pharmacogenomic analyses revealed significant differences in tum

SUBMITTER: Qin R 

PROVIDER: S-EPMC12563952 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature