Atad1 Is a Potential Candidate Gene for Prepulse Inhibition.

ABSTRACT: Background/Objectives: Prepulse inhibition (PPI) is a robust, reproducible phenotype associated with schizophrenia and other psychiatric disorders. This study was carried out to identify gene(s) influencing PPI. Methods: We performed Quantitative Trait Locus (QTL) analysis of PPI in 59 strains from the BXD recombinant inbred (BXD RI) mouse family and used a 2-LOD region for candidate gene identification. Genes significantly correlated with the candidate gene were identified based on genetic, partial, and literature correlation, and were further studied through gene enrichment and protein-protein interaction analyses. Phenome-wide association study (PheWAS) and differential expression analyses of the candidate gene were performed using human data. Results: We ide

SUBMITTER: Bajpai AK 

PROVIDER: S-EPMC12563959 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature