Blast Overpressure-Induced Neuroinflammation and Axonal Injury in the Spinal Cord of Ferrets.

ABSTRACT:

Background

Blast-induced spinal cord injuries (bSCI) account for 75% of all combat-related spinal trauma and are associated with long-term functional impairments. However, limited studies have evaluated the neuropathological outcomes in the spinal cord following blast exposure. Objectives In this study, we aimed to determine the acute and sub-acute neuropathological changes in the spinal cord of ferrets after blast exposure.

Methods

An advanced blast simulator was used to expose ferrets to tightly coupled repeated blasts. The Catwalk XT system was used to detect gait performances in ferrets at 24 h and 1 month post-blast exposure. After euthanasia, the cervical spinal cord samples were collected at 24 h or 1 month post-blast. A quantitative real-time polymerase chain reactio

SUBMITTER: Phuyal G 

PROVIDER: S-EPMC12564047 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature