Plasma Protein Biomarkers to Detect Early Gastric Preneoplasia and Cancer: A Prospective Study.

ABSTRACT: Gastric cancer (GC) often presents a poor prognosis due to its asymptomatic phenotype at early stages. Upper endoscopy, which is the current gold standard to diagnose GC, is invasive with limited sensitivity for detecting gastric preneoplasia. Non-invasive biomarkers, such as blood circulating proteins, offer a promising alternative for the early detection of gastric lesions. In this prospective study, we identified plasma protein biomarkers for gastric preneoplasia and cancer using mass spectrometry-based proteomics in an exploratory cohort (n = 39). Fifteen promising protein candidates emerged to distinguish patient categories and were further confirmed by enzyme-linked immunosorbent assays (ELISA) in plasma samples from a validation cohort of 138 participants. Our predictive models demo

SUBMITTER: Giai Gianetto Q 

PROVIDER: S-EPMC12564110 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature