PAX6 Downregulation Triggers HIF-1α-Mediated Ferroptosis in Glioma Cells.

ABSTRACT: Background: The paired-box gene 6 (PAX6) is an important transcription factor in the central nervous system, mainly regulating the development and differentiation of embryonic eyes and the nervous system. PAX6 expression is significantly decreased in glioma, and the expression levels are closely related to glioma development and prognosis. Therefore, it is important to study and elucidate the biological function of PAX6 in glioma to further our understanding of the occurrence and development of glioma. Methods: This study focused on the expression and regulation of PAX6 and hypoxia-inducing factor (HIF-1α) and investigated the molecular mechanism of ferroptosis regulated by PAX6 and HIF-1α. Firstly, immunohistochemistry, qPCR, Western blot, and other methods were used

SUBMITTER: Luo Q 

PROVIDER: S-EPMC12564151 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature