Multi-Omics Alterations in Rat Kidneys upon Chronic Glyphosate Exposure.

ABSTRACT: Clinical studies have linked glyphosate exposure to substantial morbidity, with acute kidney injury occurring in some cases. Although the toxic effects of glyphosate-based herbicides (GBHs) have been reported in several studies, their molecular impact on renal function remains poorly understood. Given the kidney's critical role in excretion, it is particularly susceptible to damage from xenobiotic exposure. In this study, we aim to identify N-glycomics and proteomics change in the kidney following chronic GBH exposure, to better understand the mechanisms behind glyphosate-induced kidney damage. Kidney tissues from female and male rats were analyzed using liquid chromatography-tandem mass spectrometry. The results revealed notable changes in the N-glycan composition, particula

SUBMITTER: Chukwubueze F 

PROVIDER: S-EPMC12564323 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature