<i>SUMF1</i> Common Variant rs793391 Is Associated with Response to Inhaled Corticosteroids in Patients with COPD.

ABSTRACT: This study investigated whether specific sulfatase modifying factor-1 (SUMF1) SNPs-previously linked to lung function-are associated with COPD progression and response to inhaled corticosteroid (ICS) treatment, specifically budesonide, given that SUMF1 expression is altered in COPD and its variants linked to increased disease risk. A subgroup of 165 COPD patients from the HISTORIC study were genotyped for two common SUMF1 SNPs, rs11915920 and rs793391. Patients first underwent a six-week run-in phase with open-label triple inhaled therapy (LAMA/LABA/ICS), then were randomized to receive either LAMA/LABA/placebo or LAMA/LABA/ICS for 12 months. Associations between SNPs, baseline characteristics, and response to ICS-based on FEV₁ change over 12 months-w

SUBMITTER: Ntenti C 

PROVIDER: S-EPMC12564353 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature