CHEcking Diagnostic Differential Ability of Real Baseline Variables and Frailty Scores in Tolerance of Anti-Cancer Systemic Therapy in OldEr Patients (CHEDDAR-TOASTIE).

ABSTRACT:

Background

Despite chemotherapy-related toxicities being more likely in older patients, no routine prediction tool has been validated for the UK population. Previous research within the TOASTIE (tolerance of anti-cancer systemic therapy in the elderly) study found a low predictive performance of the Cancer and Aging Research Group (CARG) score for severe chemotherapy-related toxicities. Building on this, the TOASTIE study dataset was used to assess the viability of developing a predictive model with baseline variables and frailty scores for severe chemotherapy-related toxicities in older patients.

Methods

All patients from the TOASTIE dataset were included, with the inclusion/exclusion criteria detailed in the TOASTIE protocol. Demographic factors, self-assessment scores, Ro

SUBMITTER: Ng HHL 

PROVIDER: S-EPMC12564391 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature