High Fat and Sugar Diet Increases Enteric cDC1 and Oral Antigen-Specific Tregs.

ABSTRACT: Diet-induced obesity is a growing global health concern linked to various immunological alterations. Dendritic cells (DCs) are major regulators of the balance between pro-inflammatory and tolerogenic immune responses. Conventional Type 1 DCs (cDC1) contribute to oral tolerance by affecting the generation of food specific regulatory T cells (Tregs). Nevertheless, whether obesity affects cDC1/Treg pathways and the generation of food tolerance remains poorly understood. Here, we investigated the spatio-temporal impact of a high-fat, high-sugar diet (HFHSD) on the enteric immune system. Enteric immune composition was primarily altered by diet and intestinal region, independently of the duration of the dietary regimen. Notably, the lamina propria of animals fed with high-caloric diet was enrich

SUBMITTER: Fischer K 

PROVIDER: S-EPMC12564431 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature