Visceral Pleural Invasion as a Determinant of Surgical Strategy in Non-Small Cell Lung Cancer: A Multicenter Study.

ABSTRACT:

Background

Visceral pleural invasion (VPI) has traditionally been regarded as a negative prognostic indicator in non-small-cell lung cancer (NSCLC). However, with the increasing adoption of sublobar resection for small-sized NSCLC, the clinical significance of VPI is being fundamentally reassessed. Specifically, it remains uncertain whether VPI is indicative of tumor size or represents distinct metastatic behavior.

Methods

We conducted a retrospective comprehensive multicenter study involving 2464 patients with pathologically confirmed NSCLC ≤ 3 cm who underwent complete resection at three Japanese institutions. The prevalence, metastatic patterns, and prognostic impact of VPI were systematically evaluated, with particular focus on histological growth patterns.

Results

SUBMITTER: Nagase W 

PROVIDER: S-EPMC12564455 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature