Application of the Combined QCM-D/LSPR Aptasensor for Penicillin G Detection.

ABSTRACT: Penicillin G (PEN) is a widely used antibiotic for treating microbial infections. However, its extensive use in veterinary medicine can lead to accumulation in animal-derived products, particularly milk and meat. This highlights the urgent need for rapid and sensitive antibiotic detection methods. In this study, we employed DNA aptamers for the detection of PEN and for the analysis of aptamer specificity using a combined approach based on quartz crystal microbalance with dissipation monitoring (QCM-D) and localized surface plasmon resonance (LSPR). QCM-D measures changes in resonant frequency, Δf, and dissipation, ΔD, while LSPR monitors wavelength shifts in the extinction spectra corresponding to changes at the surface of gold nanoparticles (AuNPs). Thiolated aptamers were c

SUBMITTER: Spagnolo S 

PROVIDER: S-EPMC12564596 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature