Interactions Between Monocarboxylate Transporter <i>MCT1</i> Gene Variants and the Kinetics of Blood Lactate Production and Removal After High-Intensity Efforts: A Cross-Sectional Study.

ABSTRACT:

Background/objectives

Lactate (LA) is a key metabolite in exercise metabolism, transported across cell membranes by monocarboxylate transporters (MCTs). Although genetic variation in MCT genes has been linked to LA kinetics, evidence in athletic populations remains limited. This study investigated nine MCT1 polymorphisms (rs4301628, rs12028967, rs10857983, rs3789592, rs10776763, rs1049434, rs6537765, rs7556664, rs7169) in relation to LA metabolism.

Methods

337 Polish and Czech males (elite athletes, sub-elite competitors, physically active controls) performed two maximal Wingate tests. Buccal swabs were collected for DNA extraction and single nucleotide polymorphism (SNP) genotyping. LA was assessed before and after the tests.

Results

Five variants (rs3789592,

SUBMITTER: Maculewicz E 

PROVIDER: S-EPMC12564665 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature