Alcohol Preference Impacts Multi-Organ Transcriptome in MetALD.

ABSTRACT:

Background/objectives

Alcohol use disorder (AUD) is a major public health issue with rising global occurrence and metabolic consequences. Modeling the addictive behaviors associated with AUD remains inadequate and elusive. Even more so, models that are representative of AUD in concert with excessive caloric intake are limited. Some consequences of chronic alcohol use overlap with the metabolic phenotype of hypercaloric diets. Recently characterized metabolic dysfunction-associated steatotic liver disease with increased alcohol intake (MetALD) helps to differentiate these conditions. This study aims to investigate metabolic phenotypes and gene expression alterations in MetALD mice that are grouped by alcohol preference based on blood phosphatidylethanol levels and alcohol consumptio

SUBMITTER: Sikhwal S 

PROVIDER: S-EPMC12564771 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature