Beyond Hyperferritinemia: Evaluating Ferritin as a Predictor of Advanced Therapy in Adult-Onset Still's Disease.

ABSTRACT: Background: Ferritin is a hallmark biomarker of systemic inflammation in adult-onset Still's disease (AOSD), but its potential role in guiding escalation to advanced therapy has not been established. This study aimed to evaluate whether ferritin, alone or in combination with simple clinical variables, could predict the need for advanced therapy in AOSD. Methods: A retrospective review was conducted of 113 patients with AOSD fulfilling the Yamaguchi criteria at Chonnam National University Hospital. Baseline demographic, clinical, and laboratory data were collected at the index episode. The primary endpoint was defined as the use of advanced therapy-namely, intravenous immunoglobulin (IVIG), anakinra, or tocilizumab-during the index hospitalization. Ferritin was log-transformed

SUBMITTER: Kang JH 

PROVIDER: S-EPMC12564851 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature