Alterations of Bioactive Lipid Profiles in the Retina Following Traumatic Optic Neuropathy in Mice.

ABSTRACT: Traumatic optic neuropathy (TON) causes vision loss through compression and contusion, yet there is no consensus on the most effective treatment. Polyunsaturated fatty acid (PUFA)-derived bioactive lipids metabolized by lipoxygenase (LOX), cytochrome P450 (CYP), and cyclooxygenase (COX) enzymes are known mediators of inflammation and neurodegeneration. However, their role in TON-related retinal pathology remains unclear. Controlled orbital impact (COI) was used to induce unilateral TON in mice with controlled velocity (2-3 m/s), with the fellow eye serving as an internal control. Retina tissues were collected three days post-injury and analyzed by LC/MS to quantify bioactive lipid metabolites from ω-6 and ω-3 PUFAs. Statistical analysis was performed using paired, nonparametric Wilcoxon si

SUBMITTER: Kim MY 

PROVIDER: S-EPMC12564875 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature