Management of Elderly Colorectal Cancer Patients: A Comprehensive Review Encompassing Geriatric Assessment.

ABSTRACT: Colorectal cancer (CRC) is a common tumor, and its incidence increases with age. Elderly CRC patients constitute a daily challenge for oncologists when deciding if they are worthy of active treatments and of which kind, as data from the literature are incomplete or even lacking in specific subsets. To fill this gap, we conducted a narrative review that included not only studies dedicated to the elderly but also extracted elderly groups from major clinical trials. Results in terms of harm and benefit were dissected according to frailty categories (fit, vulnerable, unfit). As it emerged, the management of elderly CRC patients should be based not on age alone, but rather on their frailty level, as assessed by Comprehensive Geriatric Assessment (CGA), which should be implemented in trials and

SUBMITTER: Boccaccino A 

PROVIDER: S-EPMC12564925 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature