Low-Dose Indapamide vs. Hydrochlorothiazide in Idiopathic Hypercalciuria: A Randomized Prospective Trial.

ABSTRACT: Background: Idiopathic hypercalciuria (IH) is the most common genetic metabolic disorder in patients with urinary stones and is usually treated with thiazide-type diuretics. However, direct evidence comparing low-dose indapamide and hydrochlorothiazide is scarce. This study aimed to compare their safety, efficacy and adherence in patients with IH. Methods: In this randomized prospective trial, a total of 101 patients with IH were recruited at Son Espases University Hospital (2020-2023), assigned to receive indapamide 1.5 mg/day (n = 53) or hydrochlorothiazide 25 mg/day (n = 48), and followed for 18 months. Adverse events, biochemical parameters and therapeutic adherence were evaluated. Results: A total of 90.24% patients on indapamide and 85.71% on hydrochlorothiazide

SUBMITTER: Peraire M 

PROVIDER: S-EPMC12564931 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature