Prognostic Impact of Obesity, Cardiometabolic Risk Factors, and Vascular Function Markers on Outcomes in Ischemic Cardiomyopathy.

ABSTRACT: Background/Objectives: Ischemic cardiomyopathy is a major cause of morbidity and mortality. Obesity is paradoxically associated with better outcomes, while clustering of cardiometabolic risk factors (CMRFs)-diabetes mellitus, arterial hypertension, and hyperlipidemia-is associated with worse prognosis in heart failure (HF) patients. The interplay between vascular function, obesity and clustering of CMRFs in ischemic HF is not thoroughly investigated. Methods: In a prospective, single-center cohort study, 560 patients with ischemic cardiomyopathy were followed for a median of 43 months. Baseline BMI, CMRFs and markers of vascular function including flow-mediated dilation (FMD), and carotid-femoral pulse wave velocity (cf-PWV) were assessed. Major adverse cardiovascular events

SUBMITTER: Mourouzis K 

PROVIDER: S-EPMC12565017 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature