Scaffold-Free Bone Regeneration Through Collaboration Between Type IV Collagen and FBXL14.

ABSTRACT: Background: The periosteum and periosteum-derived cells have attracted considerable attention for their potential use in clinical applications for treating bone defects. Bovine periosteum-derived cells have been investigated because of their capability for scaffold-free bone regeneration. Previous mass spectrometry (MS) and immunohistochemistry studies have shown the presence of F-box/leucine-rich repeat protein 14 (FBXL14) in bovine periosteum and periosteum-derived cells. Recently, studies using ESI-Q-Orbitrap MS suggested the presence of type IV collagen in the periosteum. The aim of the present study was to clarify the relationship between type IV collagen and FBXL14 in the formation of periosteum-derived cells. Methods: Bovine periosteum-derived cells were obtained from

SUBMITTER: Akiyama M 

PROVIDER: S-EPMC12565019 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature