First Report of <i>Candida auris</i> Candidemia in Portugal: Genomic Characterisation and Antifungal Resistance-Associated Genes Analysis.

ABSTRACT: Candida auris has emerged as a global public health threat due to its high mortality rates, multidrug resistance, and rapid transmission in healthcare settings. This study reports the first documented cases of C. auris candidemia in Portugal, comprising eight isolates from candidemia and colonised patients admitted to a major hospital in northern Portugal in 2023. Whole-genome sequencing (WGS) was performed to determine the phylogenetic relationships of the isolates, which were classified as belonging to Clade I. Genome sequencing also enabled the detection of missense mutations in antifungal resistance genes, which were correlated with antifungal susceptibility profiles determined according to EUCAST (European Committee on Antimicrobial Susceptibility Test) protocols and gui

SUBMITTER: Miranda IM 

PROVIDER: S-EPMC12565043 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature