Comparative Transcriptomics Unveils Pathogen-Specific mTOR Pathway Modulation in <i>Monochamus alternatus</i> Infected with Entomopathogenic Fungi.

ABSTRACT: Pine wilt disease (PWD), transmitted by Monochamus alternatus (JPS), poses a severe threat to global pine forests. Although the entomopathogenic fungi Beauveria bassiana (Bb) and Metarhizium anisopliae (Ma) represent environmentally friendly biocontrol alternatives, their practical application is limited by inconsistent field performance and an incomplete understanding of host-pathogen interactions. We employed dual RNA-seq at the critical 48 h infection time point to systematically compare the transcriptional responses between JPS and Bb/Ma during infection. Key findings revealed distinct infection strategies: Bb preferentially induced autophagy pathways and modulated host carbohydrate metabolism to facilitate nutrient acquisition, triggering corresponding tissue degr

SUBMITTER: Guan H 

PROVIDER: S-EPMC12565087 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature