Evolutionary Dynamics of Oncosuppression Under Selection Pressure.

ABSTRACT: Background and Objectives: Changes in the environment and physiology may be associated with an increased or decreased risk of cancer. Our study aims to evaluate the strength and the direction of the selection acting on oncosuppressor genes in association with phenotypic changes. Methods: We calculated the relative evolutionary rate (RER) using the converge method and linear regression on branches of phylogenetic trees. The association between changes in the evolutionary rate of oncosuppressors (DNA repair and cell cycle control genes) and trait selection was studied. The evolutionary rates of single oncosuppressor genes and pathways were evaluated. We studied two types of traits: those that are characteristic of vertebrates, such as homeothermy (the ability to maintain a cons

SUBMITTER: Potievskiy M 

PROVIDER: S-EPMC12565122 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature