Distinct Breast Tissue Microbiota Profiles in Early-Stage Breast Cancer: A Prospective Study in Turkish Women.

ABSTRACT: Background: This pilot study aimed to investigate the relationship between the breast tissue microbiota and breast cancer in Turkish women. We compared cancerous and adjacent normal breast tissues, as well as stool samples, obtained during breast-conserving surgery. Methods: In this prospective study, paired tumor and normal breast tissue samples, together with preoperative stool samples, were analyzed using 16S rRNA sequencing. Diversity indices and relative abundance differences were calculated, with effect sizes, 95% confidence intervals, and false discovery rate (FDR) corrections reported where appropriate. Results: A total of 22 patients with early-stage breast cancer were included (mean age 58.3 ± 12.7 years, mean BMI 28.9 ± 3.1 kg/m²). Distinct compos

SUBMITTER: Ozsaray MF 

PROVIDER: S-EPMC12565134 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature