The Synergistic Role of <i>Sargassum horneri</i> Fucoidan and <i>Lactobacillus plantarum</i>: Microbiome and Gut Barrier Restoration in Zebrafish Colitis.

ABSTRACT: Ulcerative colitis (UC) is a chronic inflammatory bowel disease marked by disruption of the intestinal barrier and gut microbiota imbalance, leading to significant impairment in patient quality of life. This study investigated the therapeutic efficacy of a synbiotic formulation composed of purified fucoidan from bloom-forming Sargassum horneri and the probiotic Lactobacillus plantarum in a dextran sulfate sodium (DSS)-induced zebrafish model of UC. Polysaccharides from S. horneri were extracted using Celluclast-assisted extraction and fractionated via DEAE anion-exchange chromatography, resulting in six fucoidan fractions. The sixth fraction (SH-F), with a molecular weight of 254 kDa, showed the highest fucose, sulfate contents, and demonstrated the highest effect on p

SUBMITTER: Liyanage NM 

PROVIDER: S-EPMC12565283 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature