Unraveling the Genome Diversity of <i>Leishmania</i> Parasites Using Next-Generation DNA Sequencing Strategies.

ABSTRACT: Parasites of the Leishmania genus are globally distributed and cause various clinical presentations in animals and humans, collectively known as leishmaniasis. The genomes of Leishmania and other trypanosomatids exhibit remarkable plasticity, shaped by several distinctive genetic features. Although these features can hinder the application of next-generation DNA sequencing (NGS) technologies, NGS data have been successfully used to characterize the whole-genome diversity of circulating Leishmania strains. The results complement and are broadly aligned with previous findings obtained with more traditional methods, offering greater resolution when working with geographically closer strains. In this review, we summarize advances over the past two decades in characterizing

SUBMITTER: Llanes A 

PROVIDER: S-EPMC12565333 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature