Developments and Assessments of Crude Tea Saponin-Incorporated Silica Nanoparticles for Their Bioactivity Improvement.

ABSTRACT: The use of saponins with biosurfactant, antioxidant, anti-inflammatory, and anti-cancer properties is limited by their toxicity and bioavailability. This study focused on the fabrication, characterization, and bioactivity of crude tea saponin (TS) and TS-incorporated silica nanoparticles (TSNPs). Our results showed that TS contained seven saponins and that TSNPs had an average diameter of 200-300 nm, a negative surface charge, and high polydispersity. Fourier Transform Infrared Spectroscopy (FTIR) revealed an incorporation bond of Si-O- and -OH controlling releasing behavior with t₅₀ = 24 h. Using HaCaT cells, it was demonstrated that TSNPs reduced cytotoxicity. Reactive oxygen species (ROS) production was lowered in both TS and TSNP treatments, with significantly greater effica

SUBMITTER: Likitsatian T 

PROVIDER: S-EPMC12565442 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature