Falling Third-Trimester Insulin Requirements in Diabetic Pregnancies and Adverse Pregnancy Outcomes: A Systematic Review and Meta-Analysis.

ABSTRACT: Background: There is conflicting evidence on whether falling insulin requirements (FIRs) in the third trimester are associated with adverse pregnancy outcomes. We synthesized published evidence to address this knowledge gap. Methods: We conducted a systematic review and meta-analysis, wherein we searched four bibliographic databases until September 04 2025 for articles describing third-trimester FIR and pregnancy outcomes. We assessed the risk of bias using the Quality In Prognosis Studies (QUIPS) tool, performed meta-analysis with pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) for maternal and perinatal outcomes and assessed certainty of evidence (CoE) using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach. Results:

SUBMITTER: D'Souza R 

PROVIDER: S-EPMC12565485 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature