The Brazilian Caatinga Biome as a Hotspot for the Isolation of Antibiotic-Producing <i>Actinomycetota</i>.

ABSTRACT: Antimicrobial resistance represents a critical global health challenge, intensifying the urgency of discovering novel antibiotics. Actinomycetota species, the most prolific source of clinical antibiotics, remain underexplored in unique ecosystems. In this study, we isolated 340 Actinomycetota strains from soils of the Brazilian semiarid Caatinga biome. Screening revealed that 122 isolates (35.9%) exhibited antimicrobial activity against clinically relevant pathogens (Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Candida albicans). Notably, 19 isolates showed activity against Mycobacterium tuberculosis H37Ra. MALDI-TOF MS analysis successfully provided genus-level identification for a subset of isolates, with approximat

SUBMITTER: Fernandes SP 

PROVIDER: S-EPMC12565491 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature