Novel Discorhabdin Derivatives from Antarctic Sponges of the Genus <i>Latrunculia</i>: Expanding the Chemical Diversity of Polar Marine Natural Products.

ABSTRACT: In this study, three Antarctic sponges of the genus Latrunculia were investigated, leading to the isolation of five unreported pyrroloiminoquinone alkaloids along with the known metabolite (+)-debromodiscorhabdin A (3). Three of the new metabolites were brominated, while the other two were found to have a C-5/C-8 sulfur bridge and a C-2/N-18 bridge. Three of the metabolites were shown to have a phenyl ketone substituent on C-14, not previously reported for discorhabdin derivatives. The cytotoxicity against the A549 cell lines was studied and compounds 1-4 showed activity of 4.3, 1.8, 1.0, and 23.9 µM, respectively, while no inhibition was found for 5 and 6.

SUBMITTER: Afoullouss S 

PROVIDER: S-EPMC12565582 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature