Microsaccade Activity During Visuospatial Working Memory in Early-Stage Parkinson's Disease.

ABSTRACT: Fixational saccadic eye movements (microsaccades) have been associated with cognitive processes, especially in tasks requiring spatial attention and memory. Alterations in oculomotor and cognitive control are commonly observed in Parkinson's disease (PD), though it is unclear to what extent microsaccade activity is affected. We acquired eye movement data from sixteen participants with early-stage PD and thirteen older healthy controls to examine the effects of dopamine modulation on microsaccade activity during the delay period of a spatial working memory task. Some microsaccade characteristics, like amplitude and duration, were moderately larger in the PD participants when they were "on" their dopaminergic medication than healthy controls, or when they were "off" medication, while PD part

SUBMITTER: Farber K 

PROVIDER: S-EPMC12565590 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature