New Polyketides and a Ferroptosis Inhibitor from the Marine-Derived Fungus <i>Diaporthe searlei</i> CS-HF-1.

ABSTRACT: As a driver of neurodegenerative disorders, ischemic injuries, and acute organ dysfunction, ferroptosis represents a therapeutic target, and its inhibition may provide novel therapies. In our ongoing efforts to discover ferroptosis inhibitors from fungal strains, chemical investigation of the strain Diaporthe searlei CS-HF-1 led to the isolation of four polyketide-derived alkaloids (1-3 and 17) and fourteen polyketides (4-16 and 18), including three new isoindolone derivatives (1-3), a new phthalide (4), a new butyrolactone derivative (10), and three new nonenolides (11-13). The structures were determined by comprehensive spectroscopic analysis. The structures of 1, 2, and 10 wer

SUBMITTER: Xiao J 

PROVIDER: S-EPMC12565626 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature