Role of Histone H3 Lysine 4 Methylation in Chromatin Biology.

ABSTRACT: Specific expression of genes is fundamental for defining the identity and the functional state of cells. Sequence-specific transcription factors interpret the information contained in DNA sequence motifs and recruit cofactors to modify chromatin and control RNA polymerases. This multi-step process typically involves several transcription factors and cofactors with different enzymatic activities. Post-translational modifications (PTMs) of histones are one key mechanism to control chromatin structure and polymerase activity and thus gene transcription. The methylation of histone H3 at lysine 4 (H3K4) is a modification of accessible chromatin, including enhancers and promoters, and also sites of recombination and some forms of DNA damage. H3K4 methylation is catalyzed by six lysine methyltran

SUBMITTER: Luscher B 

PROVIDER: S-EPMC12565824 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature