Efficacy and Safety of Intraosseous Versus Intravenous Antibiotic in Primary and Revision Total Joint Arthroplasty: A Systematic Review and Meta-Analysis.

ABSTRACT: Background and Objectives: Periprosthetic joint infection (PJI) is one of the most serious complications following total joint arthroplasty (TJA), leading to poor functional outcomes and increased healthcare burden. Intraosseous (IO) regional antibiotic prophylaxis has emerged as a promising method for infection prevention, offering potential advantages over conventional intravenous (IV) systemic administration. This study aimed to systematically evaluate the clinical evidence on the efficacy and safety of IO prophylaxis in TJA. Materials and Methods: A comprehensive literature search was conducted in PubMed, Embase, Scopus, Web of Science, and the Cochrane Library up to 23 June 2025. Eligible studies included randomized controlled trials and observational studies reporting o

SUBMITTER: Lee S 

PROVIDER: S-EPMC12565870 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature