NAD⁺-Dependent Lysine Acetylation Regulates Glucose Uptake and Fatty Acid Oxidation in Cardiomyocytes.

ABSTRACT:

Background/objectives

Stimulation of glucose uptake in response to ischemic stress is important for cardiomyocyte post-ischemic function and survival. In the diabetic myocardium chronically exposed to an excess of circulating lipids, this mechanism is impaired, making the myocardium more sensitive to ischemia-reperfusion injury (IRI). In vitro studies have shown that exposure to fatty acids (FAs) reduces basal and stimulated glucose uptake in cardiomyocytes. Preliminary results indicate reduced NAD⁺ levels and increased protein lysine acetylation in FA-exposed cardiomyocytes. This study aims to investigate whether intracellular NAD⁺ reduction is responsible for FA-induced increase in protein acetylation and impaired glucose uptake.

Methods

Primary rat c

SUBMITTER: Vanni E 

PROVIDER: S-EPMC12565917 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature